Passing through the renal clearance barrier: toward ultrasmall sizes with stable ligands for potential clinical applications

Xiao-Dong liver Zhang,1 Jiang Yang,2 Sha-Sha Song,1 Wei Long,1 Jie Chen,1 Xiu Shen,1 Hao Wang,1 Yuan-Ming Sun,1 Pei-Xun Liu,1 Saijun Fan11Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People's Republic of China; 2Department of

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TMZ-BioShuttle – a reformulated Temozolomide

There is a large number of effective cytotoxic drugs whose side effect profile, efficacy, and long-term use in man are well understood and documented over decades of use in clinical routine e.g.in the treatment of Biscuit Board And Mug recurrent glioblastoma multiforme (GBM) and the hormone-refractory prostate cancer (HRPC).Both cancers are insensi

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